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Atsushi Nakajima Selected Research

PPAR gamma

1/2010PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study.
12/2008Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine.
10/2008Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility.
4/2008Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.
11/20075-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model.
2/2007PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells.
10/2006[PPAR gamma ligand pioglitazone as a therapeutic strategy in nonalcoholic steatohepatitis (NASH)].
9/2006Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties.
5/2006Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation.
8/2005[PPARgamma and colon cancer].
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Atsushi Nakajima Research Topics

Disease

96Non-alcoholic Fatty Liver Disease
12/2022 - 10/2006
67Neoplasms (Cancer)
06/2022 - 02/2003
49Fibrosis (Cirrhosis)
11/2022 - 06/2005
31Carcinogenesis
10/2020 - 04/2002
30Inflammation (Inflammations)
01/2022 - 08/2002
29Insulin Resistance
12/2022 - 07/2002
28Hemorrhage
05/2020 - 01/2004
25Colorectal Neoplasms (Colorectal Cancer)
10/2022 - 02/2007
25Aberrant Crypt Foci
10/2020 - 04/2002
23Obesity
01/2022 - 06/2003
20Constipation
08/2022 - 01/2017
17Liver Cirrhosis (Hepatic Cirrhosis)
10/2022 - 10/2008
16Alcoholic Fatty Liver
01/2022 - 04/2005
15Liver Diseases (Liver Disease)
01/2022 - 10/2007
14Body Weight (Weight, Body)
01/2022 - 09/2002
14Adenoma (Adenomas)
10/2020 - 06/2003
13Type 2 Diabetes Mellitus (MODY)
11/2021 - 06/2006
13Colonic Neoplasms (Colon Cancer)
10/2017 - 04/2002
12Hepatocellular Carcinoma (Hepatoma)
12/2021 - 12/2004
12Pancreatic Neoplasms (Pancreatic Cancer)
07/2021 - 02/2006
12Colitis
05/2014 - 07/2002
11Polyps
10/2022 - 01/2007
11Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2017 - 07/2002
10Diabetes Mellitus
01/2022 - 11/2008
10Ulcer
09/2020 - 01/2004
9Adenocarcinoma
05/2020 - 10/2007
8Infections
01/2022 - 03/2005
7Neoplasm Metastasis (Metastasis)
06/2022 - 06/2005
6Pancreatitis
11/2021 - 12/2008
6Stomach Neoplasms (Stomach Cancer)
01/2013 - 06/2005
6Peptic Ulcer (Peptic Ulcers)
01/2012 - 01/2009
6Carcinoma (Carcinomatosis)
10/2011 - 03/2005
6Ulcerative Colitis
01/2011 - 08/2002
5Hypertension (High Blood Pressure)
12/2022 - 12/2007
5Dysbiosis
07/2021 - 01/2017
5Chronic Renal Insufficiency
02/2021 - 01/2013
5Gastroesophageal Reflux (GERD)
11/2020 - 09/2008
5Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2012 - 06/2005
5Ischemia
03/2006 - 08/2004

Drug/Important Bio-Agent (IBA)

33Biomarkers (Surrogate Marker)IBA
11/2022 - 05/2007
24PPAR gammaIBA
01/2010 - 07/2002
22Pharmaceutical PreparationsIBA
10/2021 - 11/2002
19Proteins (Proteins, Gene)FDA Link
12/2021 - 08/2002
16LigandsIBA
11/2011 - 07/2002
15Insulin (Novolin)FDA Link
01/2022 - 06/2003
14Glucose (Dextrose)FDA LinkGeneric
01/2022 - 06/2003
13LipidsIBA
12/2022 - 01/2007
13Pioglitazone (Actos)FDA Link
01/2022 - 07/2002
13Alanine Transaminase (SGPT)IBA
08/2021 - 05/2007
13Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10/2020 - 01/2009
11Capsules (Microcapsules)IBA
01/2022 - 01/2007
10elobixibatIBA
08/2022 - 01/2018
10Messenger RNA (mRNA)IBA
10/2021 - 06/2005
10Metformin (Glucophage)FDA LinkGeneric
10/2020 - 11/2008
10Triglycerides (Triacylglycerol)IBA
01/2016 - 01/2007
8Indicators and Reagents (Reagents)IBA
01/2022 - 10/2005
8Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2022 - 05/2007
8AdiponectinIBA
01/2016 - 01/2007
8LeptinIBA
09/2014 - 05/2009
8AzoxymethaneIBA
12/2013 - 04/2002
8Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
04/2008 - 07/2002
7Bile Acids and Salts (Bile Acids)IBA
05/2022 - 01/2018
7Protons (Proton)IBA
01/2022 - 01/2020
7Collagen Type IV (Type IV Collagen)IBA
01/2021 - 05/2007
7AcidsIBA
07/2017 - 01/2004
7HDL CholesterolIBA
01/2016 - 01/2007
7Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2015 - 03/2006
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2012 - 09/2002
7sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2012 - 09/2002
7Dextrans (Dextran)FDA Link
01/2012 - 09/2002
6EnzymesIBA
08/2022 - 06/2003
6EndotoxinsIBA
07/2021 - 07/2012
6GemcitabineFDA Link
04/2021 - 02/2006
6Therapeutic UsesIBA
03/2021 - 07/2012
6Hemoglobins (Hemoglobin)IBA
02/2021 - 12/2002
6BiguanidesIBA
10/2020 - 11/2008
6Ferritins (Ferritin)IBA
06/2015 - 10/2005
6Dehydroepiandrosterone (DHEA)IBA
02/2007 - 04/2002
6CytokinesIBA
11/2006 - 07/2002
5bile acid binding proteinsIBA
07/2022 - 01/2018
5Peroxisome Proliferator-Activated Receptors (PPAR)IBA
06/2022 - 01/2012
5Opioid Analgesics (Opioids)IBA
04/2022 - 03/2018
5CholesterolIBA
01/2022 - 01/2008
5Methylene Blue (Methylthioninium Chloride)FDA Link
10/2020 - 01/2012
5Proton Pump InhibitorsIBA
09/2020 - 11/2009
5LDL CholesterolIBA
06/2020 - 01/2007
5oxidized low density lipoproteinIBA
06/2020 - 01/2007
5Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
10/2019 - 01/2009
5AntigensIBA
01/2019 - 02/2004
5CarcinogensIBA
09/2014 - 05/2006
5microsomal triglyceride transfer proteinIBA
05/2014 - 09/2009
5Transcription Factors (Transcription Factor)IBA
05/2011 - 03/2005
4Glucagon-Like Peptide 1 (GLP 1)IBA
01/2022 - 03/2020
4IronIBA
01/2022 - 10/2005

Therapy/Procedure

57Therapeutics
06/2022 - 08/2002
18Drug Therapy (Chemotherapy)
09/2021 - 02/2006
11Chemoprevention
08/2020 - 04/2002
9Stents
07/2021 - 01/2011
8Liver Transplantation
11/2022 - 03/2011
4Oral Administration
12/2022 - 12/2002